Deepfakes are not just another cybersecurity risk. They can strike at the heart of corporate credibility and undermine everyday business interactions. AI-based detection tech is improving and may help combat the threat but is untested. Thus, a comprehensive program is needed to strengthen defenses and the response. With insights and recommendations from practitioners at Baker Donelson, DeleteMe, Fisher Phillips and Gartner, this article provided a detailed framework for mitigating deepfake risk and presented pitfalls to avoid in the battle against this pervasive fraud.